関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Bromopyridine | HCID 7973 | — |
| 反応物 | 2,3-Dichloro-4-methoxybenzaldehyde | HCID 13015689 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | alpha-(2,3-Dichloro-4-methoxyphenyl)-2-pyridinemethanol | HCID 13015690 | — |
反応手順
29.3 g of 2-bromopyridine in 150 ml of dry THF is added to 75 ml of 2.6M n-butyllithium that was chilled to -65° C. 2,3-dichloro-4-methoxybenzaldehyde (38.0 g) is then added in 300 ml of THF and the reaction mixture allowed to come to room temperature. It is poured into H2O and the crystalline product filtered off, washed with ether and dried to give α-(2,3-dichloro-4-methoxyphenyl)-2-pyridinemethanol, mp 174°-176° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04728662 |
|---|
| 出典データセット | uspto-grants-1988_03 |
|---|
| ORD ID | ord-386848d5c489420ea7ebd52b0c9b35f7 |
|---|
| 出典メモ | uspto-grants-1988_03 |
|---|
