2,3-Dichloroanisole → 2,3-Dichloro-4-methoxy-4'-fluorobenzophenone

HRID 568647

反応式

HRID 568647 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[Cl:11][C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[O:19][CH3:20].[Al+3].[Cl-].[Cl-].[Cl-]>ClCCCl>[Cl:18][C:17]1[C:12]([Cl:11])=[C:13]([O:19][CH3:20])[CH:14]=[CH:15][C:16]=1[C:6]([C:5]1[CH:9]=[CH:10][C:2]([F:1])=[CH:3][CH:4]=1)=[O:7]

参加物

5

反応物 3

HCID 161262,3-DichloroanisoleHCID 678794-Fluorobenzoyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 201506312,3-Dichloro-4-methoxy-4'-fluorobenzophenone

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

The Friedel-Crafts procedure of Example 24a is repeated with 31.55 g of p-fluorobenzoyl chloride, 32 g of 2,3-dichloroanisole and 35.22 g of AlCl3 combined in 1,2-dichloroethane and reacted. The resultant crude product is triturated with warm hexane, cooled and filtered to yield 2,3-dichloro-4-methoxy-4'-fluorobenzophenone.

後処理

  1. customreacted
  2. customThe resultant crude product is triturated with warm hexane
  3. temperaturecooled
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-0cdad6fa654a491e90f7ef1e1e3944e1
出典データセット
uspto-grants-1988_03
特許番号
US04728662

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