Pyridinium chloride → 2,3-Dichloro-4-hydroxy-4'-fluorobenzophenone
反応式
[Cl:1][C:2]1[C:16]([Cl:17])=[C:15]([O:18]C)[CH:14]=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=[O:5].Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[C:16]([Cl:17])=[C:15]([OH:18])[CH:14]=[CH:13][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][C:9]([F:12])=[CH:10][CH:11]=1)=[O:5]参加物
3
反応条件
- 温度
- 200 °C
実験手順
A mixture of 39.5 g of 2,3-dichloro-4-methoxy-4'-fluorobenzophenone and 160 g of pyridine hydrochloride is heated at 200° C. for one hour. The reaction mixture is poured into ice water with stirring and a precipitate forms. The precipitate is filtered and dried for about 18 hours to yield 2,3-dichloro-4-hydroxy-4'-fluorobenzophenone.
後処理
- filtrationThe precipitate is filtered
- customdried for about 18 hours
出典と根拠
- ORDレコード
- ord-141736b1040f4f7890ebde6cb00d9c9d
- 出典データセット
- uspto-grants-1988_03
- 特許番号
- US04728662
反応ノート
読み込み中…