関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-(2-(2-Chloroethoxy)ethoxy)ethanol | HCID 78871 | — |
| 生成物 | Triethyl 2-[2-(2-hydroxy-ethoxy)ethoxy]ethylammonium chloride | HCID 13765545 | 95% |
反応手順
An autoclave (capacity: 500 ml) was charged with 200 parts of methanol and 94.5 parts of triethylamine. After heating the mixture to 130° C., 135 parts of 2-[2-(2-chloro-ethoxy)ethoxy]ethanol was added over a period of 1 hour and the resulting mixture was heated at 130° C. for an additional 4 hours. Crystallization was performed as in Preparation 1 to obtain 205.0 parts of triethyl 2-[2-(2-hydroxy-ethoxy)ethoxy]ethylammonium chloride (yield: 95%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04729941 |
|---|
| 出典データセット | uspto-grants-1988_03 |
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| ORD ID | ord-26b0fae42e79469cbdc05ee0a34b39ab |
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| 出典メモ | uspto-grants-1988_03 |
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