Triethylamine → 3-Methoxyphenethyl mesylate
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[CH2:6][CH2:7][OH:8].C(N(CC)CC)C.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>C(Cl)Cl>[CH3:19][S:20]([O:8][CH2:7][CH2:6][C:5]1[CH:9]=[CH:10][CH:11]=[C:3]([O:2][CH3:1])[CH:4]=1)(=[O:22])=[O:21]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a flask under argon was added 10.1 g (0.0661 mole) 3-methoxyphenethyl alcohol, 150 mL methylene chloride and 9.2 ml (0.0661 mole) triethylamine. The solution was cooled to 0° C. and 5.1 ml (0.0661 mole) methanesulfonyl chloride was added slowly. The reaction mixture was warmed to room temperature. After 24 hr, the reaction was washed with water and brine, and dried with MgSO4. The solvent was evaporated in vacuo to give 15.0 g of the product as a clear oil.
後処理
- temperatureThe reaction mixture was warmed to room temperature
- washthe reaction was washed with water and brine
- dry with materialdried with MgSO4
- customThe solvent was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-6c28129db84e4fc69e5d5e66e6fd20c1
- 出典データセット
- uspto-grants-1988_03
- 特許番号
- US04729994
反応ノート
読み込み中…