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(+/-)-cis-1-Methylethyl 6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane4-acetate → Atorvastatin Impurity 206
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (+/-)-cis-1-Methylethyl 6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane4-acetate | HCID 10999646 | — |
| 触媒 | Adams' catalyst | HCID 345198 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | Atorvastatin Impurity 206 | HCID 11139823 | — |
反応手順
A mixture of (±)-cis-1-methylethyl 6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetate, 0.55 g, in glacial acetic acid is hydrogenated with platinum dioxide at 50 pounds per square inch (PSI). Concentration, dilution with ethyl acetate and bicarbonate wash, followed by washing with brine and drying provides 250 mg of (±)-cis-1-methylethyl 6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate. MS 260.1, 244.1
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05245047 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-1a331950e4dd4997b61684a90a5e772a |
| 出典メモ | uspto-grants-1993_09 |