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Hydrochloric Acid → 4-Acetoxymethylindole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 1H-indol-4-ylmethanol | HCID 2773457 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-Acetoxymethylindole | HCID 20132383 | — |
反応手順
4-Hydroxymethylindole (17 g) is heated in pyridine (12 ml) with acetic anhydride (11.9 ml) for three hours on the steam bath. After dilution with ether, the reaction mixture is first shaken out with 1N hydrochloric acid, then with saturated sodium bicarbonate solution and finally with water. The ether solution is evaporated. 20 g of 4-acetoxymethylindole remains.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04731365 |
| 出典データセット | uspto-grants-1988_03 |
| ORD ID | ord-f5a6e312d5b741aaa43bf70079b5d383 |
| 出典メモ | uspto-grants-1988_03 |