Ethanol → 1-Chloro-5-(4-chlorophenoxy)-3,3-dimethylpentan-2-one

HRID 569199ノート

反応式

HRID 569199 の反応式
[Cl:1][C:2](OC1C=CC(Cl)=CC=1)=[CH:3][C:4]([CH3:16])([CH3:15])[CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1.C([OH:27])C>Cl>[Cl:1][CH2:2][C:3](=[O:27])[C:4]([CH3:16])([CH3:15])[CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 702EthanolHCID 54255953HCID 54255953、化合物

生成物 1

HCID 133228741-Chloro-5-(4-chlorophenoxy)-3,3-dimethylpentan-2-one収率 88%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

580 g (1.5 mols) of 1-chloro-3,3-dimethyl-1,5-di-(4-chlorophenoxy)-1-pentene in 1,000 ml of ethanol and 300 ml of concentrated hydrochloric acid are heated under reflux for 4 hours. The ethanol is removed in vacuo, and the residue is diluted with methylene chloride and extracted by shaking with water, and then three times with dilute sodium hydroxide solution. The dried solution is freed of solvent in vacuo. 363 g (88% of theory) of 1-chloro-5-(4-chlorophenoxy)-3,3-dimethyl-2-pentanone are obtained as an oil.

後処理

  1. temperatureunder reflux for 4 hours
  2. customThe ethanol is removed in vacuo
  3. additionthe residue is diluted with methylene chloride
  4. extractionextracted

出典と根拠

ORDレコード
ord-d66122ce2dde4cf5be909e71f315066e
出典データセット
uspto-grants-1988_03
特許番号
US04731452

反応ノート

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