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2-Chloro-6-(1-piperazinyl)pyrazine → 2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-3a,4,7,7a-tetrahydro-5,6-dimethyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide, dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-6-(1-piperazinyl)pyrazine | HCID 107992 | — |
| 反応物 | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| 反応物 | 3a,4,7,7a-tetrahydro-5,6-dimethyl-1,2-benzisothiazol-3-(2H)-one 1,1-dioxide | HCID 12477038 | — |
| 生成物 | 2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-3a,4,7,7a-tetrahydro-5,6-dimethyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide, dihydrochloride | HCID 88521857 | — |
反応手順
The title compound is prepared using the procedure of Example 1 using 3a,4,7,7a-tetrahydro-5,6-dimethyl-1,2-benzisothiazol-3-(2H)-one 1,1-dioxide instead of 3a,4,7,7a-tetrahydro-4,7-methano-1,2-benzisothiazol-3(2H)-one 1,1-dioxide and 1-(6-chloro-2-pyrazinyl)piperazine instead of 4-(2-pyrimidinyl)piperazine. The final product is converted to its dihydrochloride salt, mp 158°-160° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04732984 |
| 出典データセット | uspto-grants-1988_03 |
| ORD ID | ord-4931d279d7594679a4d32efc8e4fd4c1 |
| 出典メモ | uspto-grants-1988_03 |