Tetraethyl (phenoxymethylene)-bisphosphonate → (Phenoxymethylene)-bisphosphonic acid
反応式
[O:1]([CH:8]([P:17](=[O:24])([O:21]CC)[O:18]CC)[P:9](=[O:16])([O:13]CC)[O:10]CC)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Cl>[O:1]([CH:8]([P:17](=[O:18])([OH:21])[OH:24])[P:9](=[O:10])([OH:13])[OH:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
A mixture of tetraethyl (phenoxymethylene)-bisphosphonate (20 g) and 6N hydrochloric acid (150 ml) was refluxed overnight and the resulting solution was evaporated to dryness in vacuo. Residual hydrochloric acid was removed by repeated evaporation with absolute ethanol. The residue was taken up in acetone (7 ml) and ether (200 ml) was added. The crystalline product was filtered, washed with ether and dried in vacuo.
後処理
- temperaturewas refluxed overnight
- customthe resulting solution was evaporated to dryness in vacuo
- customResidual hydrochloric acid was removed
- customevaporation with absolute ethanol
- additionether (200 ml) was added
- filtrationThe crystalline product was filtered
- washwashed with ether
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-fed28e7d18344f6e97ba7c2d9727c9ab
- 出典データセット
- uspto-grants-1988_03
- 特許番号
- US04732998
反応ノート
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