化工社化工社 化学情報印刷レポート · 研究参考用
Diisobutylaluminum hydride → (1H-indol-5-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisobutylaluminum hydride | HCID 14487 | — |
| 反応物 | methyl 1H-indole-5-carboxylate | HCID 2737635 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | (1H-indol-5-yl)methanol | HCID 2773458 | — |
反応手順
96 g (0.548 mole) of 6b are treated analogously to Example 1a in 1,800 ml of ether and 1,391 ml (1.67 moles) of DIBAL (1.2 molar in toluene). After chromatography on silica gel with gradient elution with petroleum ether/ethyl acetate (3:1) and petroleum ether/ethyl acetate (1:1), 39.3 g (49%) of pure product are obtained. C9H9NO (147.2)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04734407 |
| 出典データセット | uspto-grants-1988_03 |
| ORD ID | ord-bc1b83dde3684cc4aa27d378a6abf204 |
| 出典メモ | uspto-grants-1988_03 |