2,5-Dimethoxytetrahydrofuran → 6-(4-pyrrol-1-ylphenyl)-4,5-dihydro-2H-pyridazin-3-one

HRID 569771ノート

反応式

HRID 569771 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.CO[CH:17]1[CH2:21][CH2:20][CH:19](OC)O1>C(O)(=O)C>[N:1]1([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[CH2:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=3)=[CH:4][CH:3]=2)[CH:17]=[CH:21][CH:20]=[CH:19]1

参加物

4

反応物 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 108670826-(4-aminophenyl)-2H-pyridazin-3-one

生成物 1

HCID 201463216-(4-pyrrol-1-ylphenyl)-4,5-dihydro-2H-pyridazin-3-one収率 25.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 6-(4-aminophenyl)-3(2H)-pyridazinone (3.7 g) and 2,5-dimethoxytetrahydrofuran (2.6 g) in glacial acetic acid (37 ml) is heated under reflux for four hours. The reaction mixture is cooled, filtered and the solid is washed with ethanol, and finally crystallized from methanol to give 1.2 g of the product, 4,5-dihydro-6-[4-(1H)-pyrrol-1-yl)phenyl]-3(2H)-pyridazinone, mp 222°-223° C.

後処理

  1. temperatureis heated
  2. temperatureunder reflux for four hours
  3. temperatureThe reaction mixture is cooled
  4. filtrationfiltered
  5. washthe solid is washed with ethanol
  6. customfinally crystallized from methanol

出典と根拠

ORDレコード
ord-0bfde153d865463e8e0d1d61e8c94efe
出典データセット
uspto-grants-1988_03
特許番号
US04734415

反応ノート

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