関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | 2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide | HCID 14458995 | — |
| 生成物 | 7-Bromo-3-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazoline | HCID 14459003 | — |
反応手順
2-Amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide (2.90 g) and N,N'-carbonyldiimidazole (4.68 g) were dissolved in dioxane (50 ml). The solution was evaporated to give a residue, which was stirred at 150° C. for 30 minutes. After cooling, the precipitates were collected by filtration and washed with ethanol to give 7-bromo-3-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazoline (2.92 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04734419 |
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| 出典データセット | uspto-grants-1988_03 |
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| ORD ID | ord-972835d6878a434e94518b5c14195c7f |
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| 出典メモ | uspto-grants-1988_03 |
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