Methyl Acrylate → Methyl 3-(phenylthio)propionate

HRID 569942ノート

反応式

HRID 569942 の反応式
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCN(CC)CC.[C:15]([O:19][CH3:20])(=[O:18])[CH:16]=[CH2:17]>C(Cl)Cl>[C:1]1([S:7][CH2:17][CH2:16][C:15]([O:19][CH3:20])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 7294Methyl AcrylateHCID 7969ThiophenolHCID 8471Triethylamine

生成物 1

HCID 350367Methyl 3-(phenylthio)propionate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Thiophenol (440 mg, 4 mmol) and Et3N (70 μ1, 0.5 mmol) were dissolved in CH2Cl2 (5 ml). Methyl acrylate (412 mg, 4.8 mmol) was added dropwise. The reaction was exothermic. After stirring at room temperature for 30 minutes, the excess methyl acrylate was removed in vacuo. TLC: silica gel, Et2O-hexane 1:2, UV Rf =0.58. The crude title ester was used without further purification.

後処理

  1. customthe excess methyl acrylate was removed in vacuo
  2. customThe crude title ester was used without further purification

出典と根拠

ORDレコード
ord-c85e2182699e4d24be8cca38331546e8
出典データセット
uspto-grants-1988_03
特許番号
US04734424

反応ノート

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