Hydrochloric Acid → HCID 12899415、化合物
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:13]C(=O)C)=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2.Cl>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2参加物
3
実験手順
The thus-obtained 21 g of 8-bromo-5-acetyloxy-3,4-dihydrocarbostyril are dispersed in 150 ml of 8N-hydrochloric acid. The dispersion is heated under reflux conditions for 3 hours and then cooled. Insoluble matter thus formed is separated by filtration, washed with water and dried, and recrystallized from methanol-water to obtain 14 g of 8-bromo-5-hydroxy-3,4-dihydrocarbostyril in the form of colorless needle-like crystals with a melting point of 212°-213° C.
後処理
- temperatureThe dispersion is heated under reflux conditions for 3 hours
- temperaturecooled
- customInsoluble matter thus formed
- customis separated by filtration
- washwashed with water
- customdried
- customrecrystallized from methanol-water
出典と根拠
- ORDレコード
- ord-5b284d439d07405a8c9d94bf80207417
- 出典データセット
- uspto-grants-1988_03
- 特許番号
- US04734416
反応ノート
読み込み中…