Ethylamine → Ethyl N-ethyl-beta-alaninate

HRID 569987

反応式

HRID 569987 の反応式
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].[CH2:8]([NH2:10])[CH3:9]>C(O)C>[CH2:8]([NH:10][CH2:3][CH2:2][C:1]([O:5][CH2:6][CH3:7])=[O:4])[CH3:9]

参加物

4

反応物 2

HCID 6341EthylamineHCID 8821Ethyl Acrylate

生成物 1

HCID 90223Ethyl N-ethyl-beta-alaninate収率 70%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Dissolved in 500 ml of ethanol was 50 g (0.50 mol) of ethyl acrylate. While stirring the thus-prepared solution while ice cooling, a liquid mixture of 36 g (0.55 mol) of a 70% aqueous solution of ethylamine and 100 ml of ethanol was added dropwise over 3.5 hours. After allowing the reaction to proceed for further 3 hours, the solvents were distilled off. The residue was distilled under reduced pressure to obtain 50.5 g of the intended product as colorless liquid (yield: 70%).

後処理

  1. additionwas added dropwise over 3.5 hours
  2. customthe reaction
  3. distillationthe solvents were distilled off
  4. distillationThe residue was distilled under reduced pressure

出典と根拠

ORDレコード
ord-10088b2b9c864693af3568ed4f03413f
出典データセット
uspto-grants-1988_03
特許番号
US04734418

関連ノート

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