Hydrochloric Acid → 1-Ethylpiperidine-2,4-dione

HRID 569989ノート

反応式

HRID 569989 の反応式
C([CH:6]1[C:11](=[O:12])[CH2:10][CH2:9][N:8]([CH2:13][CH3:14])[C:7]1=[O:15])(OCC)=O.Cl>>[CH2:13]([N:8]1[CH2:9][CH2:10][C:11](=[O:12])[CH2:6][C:7]1=[O:15])[CH3:14]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 13784118Ethyl 1-Ethyl-2,4-dioxopiperidine-3-carboxylate

生成物 1

HCID 137841191-Ethylpiperidine-2,4-dione収率 70%

実験手順

Added to 36.0 g of 3-carboethoxy-1-ethylpiperidine-2,4-dione (Referential Example 35) was 300 ml of a 10% aqueous solution of hydrochloric acid. The resultant mixture was refluxed for 40 minutes. After allowing the reaction mixture to cool down, it was extracted with chloroform. The chloroform layer was washed with water, dried and then concentrated, thereby obtaining 16.6 g of 1-ethylpiperidine-2,4-dione as a light yellowish oily substance (yield: 70%).

後処理

  1. temperatureto cool down
  2. extractionit was extracted with chloroform
  3. washThe chloroform layer was washed with water
  4. customdried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-03264042118a435a924dd981a1008270
出典データセット
uspto-grants-1988_03
特許番号
US04734418

反応ノート

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