Ammonium Hydroxide → HCID 13784124、化合物

HRID 569993ノート

反応式

HRID 569993 の反応式
Cl[CH2:2][C:3]1[C:8]([C:9](OCC)=[O:10])=[CH:7][N:6]=[C:5]([N:14]2[CH2:19][CH2:18][N:17]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:16][CH2:15]2)[N:4]=1.[NH4+:27].[OH-].C([O-])(O)=O.[Na+]>C(O)C>[CH2:20]([N:17]1[CH2:16][CH2:15][N:14]([C:5]2[N:6]=[CH:7][C:8]3[C:9](=[O:10])[NH:27][CH2:2][C:3]=3[N:4]=2)[CH2:19][CH2:18]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

参加物

5

反応物 3

HCID 14923Ammonium HydroxideHCID 516892Sodium BicarbonateHCID 13769878Ethyl 4-(chloromethyl)-2-[4-(phenylmethyl)-1-piperazinyl]-5-pyrimidinecarboxylate

生成物 1

HCID 13784124HCID 13784124、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Dissolved in 10 ml of ethanol was 2.25 g (6 mmol) of ethyl 4-chloromethyl-2-(4-benzylpiperazino)pyrimidine-5-carboxylate (Referential Example 41), followed by an addition of 10 ml (59 mmol) of a 30% aqueous NH4OH solution at 20° C. The resultant mixture was stirred for 12 hours. The reaction mixture was poured in a 10% aqueous NaHCO3 solution, followed by extraction with CHCl3. The solvent was then distilled off and the residue was recrystallized from toluene.

後処理

  1. extractionfollowed by extraction with CHCl3
  2. distillationThe solvent was then distilled off
  3. customthe residue was recrystallized from toluene

出典と根拠

ORDレコード
ord-673874d9d64e45babc7ad0f4104005f3
出典データセット
uspto-grants-1988_03
特許番号
US04734418

反応ノート

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