Piperazine → 2-Piperazino-6,7-dimethoxyquinazoline

HRID 570011ノート

反応式

HRID 570011 の反応式
Cl[C:2]1[N:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([O:12][CH3:13])[CH:8]=2)[N:3]=1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>C(O)CC(C)C>[N:16]1([C:2]2[N:11]=[CH:10][C:9]3[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([O:12][CH3:13])[CH:8]=3)[N:3]=2)[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1

参加物

4

反応物 2

HCID 4837PiperazineHCID 18181442-Chloro-6,7-dimethoxyquinazoline

生成物 1

HCID 137841852-Piperazino-6,7-dimethoxyquinazoline収率 91%

試薬・触媒・溶媒 1

HCID 31260Isoamyl Alcohol溶媒

実験手順

Refluxed for 2 hours in isoamyl alcohol (15 ml) were 0.63 g of 2-chloro-6,7-dimethoxyquinazoline (synthesized by the method described in Japanese Patent Laid-Open No. 36390/1972) and 0.72 g of anhydrous piperazine. Isoamyl alcohol was thereafter distilled off under reduced pressure, followed by extraction with 2N--NaOH and chloroform. The chloroform layer was washed with saturated saline and then dried with anhydrous magnesium sulfate. Chloroform was distilled off under reduced pressure to obtain 0.7 g of the intended product (yield: 91%).

後処理

  1. customsynthesized by the method
  2. distillationIsoamyl alcohol was thereafter distilled off under reduced pressure
  3. extractionfollowed by extraction with 2N
  4. washThe chloroform layer was washed with saturated saline
  5. dry with materialdried with anhydrous magnesium sulfate
  6. distillationChloroform was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-021aededadf048898074c8fd46bc7614
出典データセット
uspto-grants-1988_03
特許番号
US04734418

反応ノート

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