2-Propenoic acid, 2-[(methoxycarbonyl)amino]-, methyl ester → Methyl alpha-isocyanatoacrylate
反応式
C[O:2][C:3]([NH:5][C:6](=[CH2:11])[C:7]([O:9][CH3:10])=[O:8])=O>C1(C)C=CC=CC=1>[N:5]([C:6](=[CH2:11])[C:7]([O:9][CH3:10])=[O:8])=[C:3]=[O:2]参加物
3
反応条件
- 温度
- -78 °C
実験手順
The apparatus and procedure used in Example 6 are repeated except that the tube is filled with silica-alumina (Strem, 87% silica, 52.39 g after drying). A solution of methyl alpha-(methoxycarbonylamino)-acrylate (5.86 g, 0.37 mmol) in 10 ml toluene is passed down the column. Both traps are cooled to -78° C., and the contents are combined for analysis. 1H NMR of the reaction products (14.2 g including toluene) indicated a 90% conversion of starting material and a 50% yield of isocyanate.
後処理
- additionis filled with silica-alumina (Strem, 87% silica, 52.39 g after drying)
出典と根拠
- ORDレコード
- ord-da4e094d1f0149c6b8346c6e5b6db774
- 出典データセット
- uspto-grants-1988_03
- 特許番号
- US04734453
反応ノート
読み込み中…