4-Chloro-3-(trifluoromethyl)benzaldehyde → 3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carboxylic acid [2-(4-chloro-3-trifluoromethyl-benzylamino)-ethyl]-amide

関与物質

反応手順

This compound was prepared in an analogous manner as 3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carboxylic acid [2-(4-methoxy-benzylamino)-ethyl]-amide using 4-chloro-3-(trifluoromethyl)benzaldehyde instead of 4-methoxy benzaldehyde. LCMS (ESI) 494 (M+H) 1H NMR (400 MHz, DMSO-d6) δ ppm 11.52 (1H, br. s.) 10.28 (1H, s) 7.95-8.09 (2H, m) 7.81 (1H, s) 7.77 (1H, d, J=5.42 Hz) 7.56-7.64 (2H, m) 7.47 (1H, d, J=5.42 Hz) 7.29 (1H, dd, J=3.27, 2.64 Hz) 6.80 (1H, d, J=5.47 Hz) 6.42 (1H, dd, J=3.51, 1.90 Hz) 3.75 (2H, s) 3.34 (2H, d, J=5.95 Hz) 2.62 (2H, t, J=6.56 Hz)

情報源と証拠