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HRID 57057作成日：2026年10月26日

2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoic acid → HCID 178495086、化合物

https://huagongshe.com/reaction/57057

反応式

関与物質

役割名称HCID仕込み量
反応物2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoic acidHCID 117622944—
反応物HCID 178507360HCID 178507360—
生成物HCID 178495086HCID 178495086—

反応手順

170 mg (451 μmol) of 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoic acid (racemate) and 92.4 mg (purity 90%, 496 μmol, 1.1 eq.) of 5-amino-3-chloro-1H-indazole were reacted according to General Method 1. The crude product was purified by flash chromatography (silica gel 50, cyclohexane/ethyl acetate mixtures). Yield: 113 mg (48% of theory)

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09434690B2
出典データセットuspto-grants-2016_09
ORD IDord-cf3232d8358e461a85db5812abcc168f
出典メモuspto-grants-2016_09