Hydrochloric Acid → 4-(3-Butyl-4-cyano-2-methylpyrrole-1-yl)benzoic acid

HRID 570835ノート

反応式

HRID 570835 の反応式
C([O:3][C:4](=[O:23])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:15]=[C:14]([C:16]#[N:17])[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[C:12]2[CH3:22])=[CH:7][CH:6]=1)C.O.[OH-].[Li+].Cl>C(O)C.O>[CH2:18]([C:13]1[C:14]([C:16]#[N:17])=[CH:15][N:11]([C:8]2[CH:7]=[CH:6][C:5]([C:4]([OH:23])=[O:3])=[CH:10][CH:9]=2)[C:12]=1[CH3:22])[CH2:19][CH2:20][CH3:21]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 594780574-(3-Butyl-4-cyano-2-methylpyrrole-1-yl)benzoic acid ethyl ester

生成物 1

HCID 594777644-(3-Butyl-4-cyano-2-methylpyrrole-1-yl)benzoic acid収率 98.9%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

A suspension of 4-(3-butyl-4-cyano-2-methylpyrrole-1-yl)benzoic acid ethyl ester (0.030 g) and lithium hydroxide mono hydrate (0.041 g) in ethanol (2 mL) and water (1 mL) was stirred at 50° C. for 2 hours. To this reaction mixture was added 1 mol/L hydrochloric acid (5 mL), and this mixture was stirred at room temperature for 30 minutes. This reaction mixture was extracted with ethyl acetate, and this organic layer was washed with water, dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (0.027 g).

後処理

  1. stirringthis mixture was stirred at room temperature for 30 minutes
  2. extractionThis reaction mixture was extracted with ethyl acetate
  3. washthis organic layer was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-339af673c05048f6ad5bbc8041fe35a8
出典データセット
uspto-grants-2015_05
特許番号
US09023882B2

反応ノート

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