関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | trans-N,N'-dimethyl-1,2-cyclohexanediamine | HCID 2733821 | — |
| 反応物 | 4-Phenyl-1H-pyrrole-3-carbonitrile | HCID 3721460 | — |
| 反応物 | Ethyl 2-bromoisonicotinate | HCID 3847769 | — |
| 触媒 | Copper iodide | HCID 83717 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(3-Cyano-4-phenylpyrrole-1-yl)isonicotinic acid ethyl ester | HCID 59477832 | 35% |
反応手順
To a solution of 4-phenyl-1H-pyrrole-3-carbonitrile (0.1 g) in toluene (0.70 mL) were added 2-bromo-isonicotinic acid ethyl ester (0.19 g), potassium phosphate (0.31 g), (1R,2R)-(−)-N,N′-dimethylcyclohexane-1,2-diamine (0.02 g) and copper iodide (0.007 g) at room temperature, and this mixture was stirred at 110° C. for 24 hours. The insoluble material was removed by filtration through Celite, and this filtrate was concentrated. This obtained residue was purified by column chromatography on silica gel (eluent: ethyl acetate/n-hexane=10/90-66/34) to give the title compound (0.066 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09023882B2 |
|---|
| 出典データセット | uspto-grants-2015_05 |
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| ORD ID | ord-fea73fa641114481b0084c1ccb5dd478 |
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| 出典メモ | uspto-grants-2015_05 |
|---|
