Methanol → 2-(3-Cyano-4-phenylpyrrole-1-yl)-5-hydroxyisonicotinic acid ethyl ester

HRID 570855ノート

反応式

HRID 570855 の反応式
[CH2:1]([O:3][C:4](=[O:32])[C:5]1[C:10]([O:11]CC2C=CC=CC=2)=[CH:9][N:8]=[C:7]([N:19]2[CH:23]=[C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:21]([C:30]#[N:31])=[CH:20]2)[CH:6]=1)[CH3:2].CO>[C].[Pd].C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[O:32])[C:5]1[C:10]([OH:11])=[CH:9][N:8]=[C:7]([N:19]2[CH:23]=[C:22]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:21]([C:30]#[N:31])=[CH:20]2)[CH:6]=1)[CH3:2]

参加物

5

反応物 2

HCID 887MethanolHCID 594778055-Benzyloxy-2-(3-cyano-4-phenylpyrrole-1-yl)isonicotinic acid ethyl ester

生成物 1

HCID 594778862-(3-Cyano-4-phenylpyrrole-1-yl)-5-hydroxyisonicotinic acid ethyl ester

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 5-benzyloxy-2-(3-cyano-4-phenylpyrrole-1-yl)isonicotinic acid ethyl ester in a mixed solvent of methanol (2 mL) and ethyl acetate (2 mL) was added palladium-carbon powder (0.020 g), and this mixture was stirred at room temperature under a hydrogen atmosphere for 30 minutes. The insoluble material was removed by suction through a Celite pad. This filtrate was concentrated under reduced pressure. This obtained solid was washed with diethyl ether, dried to give the title compound (0.040 g).

後処理

  1. customThe insoluble material was removed by suction through a Celite pad
  2. concentrationThis filtrate was concentrated under reduced pressure
  3. washThis obtained solid was washed with diethyl ether
  4. customdried

出典と根拠

ORDレコード
ord-08559025f9664fcd9c76a4c512d0a3ca
出典データセット
uspto-grants-2015_05
特許番号
US09023882B2

反応ノート

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