HCID 178481978、化合物 → HCID 178481971、化合物
反応式
I.[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13](=[NH:24])[NH:14][CH2:15][C:16](=O)[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[C:6]2[N:5]=[N:4]1>Cl>[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13]3[NH:14][CH:15]=[C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:24]=3)=[C:6]2[N:5]=[N:4]1参加物
3
反応条件
- 温度
- 80 °C
実験手順
A mixture of crude 3-methyl-4-oxo-N-(2-oxo-2-phenylethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide (250 mg) in 3N HCl (17 mL) was heated at 80° C. overnight. After being cooled to room temperature, the mixture was left at 4° C. for 1 hour and the precipitate was filtered and washed successively with cold water, ethyl acetate and diethyl ether to give a 97:3 mixture of hydrochloride and hydroiodide salt (elemental analysis) of the title compound.