Hydrogen iodide → HCID 178481972、化合物

HRID 570946ノート

反応式

HRID 570946 の反応式
I.[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13](=[NH:23])[NH:14][CH2:15][C:16](=O)[C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)=[C:6]2[N:5]=[N:4]1.I>Cl>[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13]3[NH:14][CH:15]=[C:16]([C:17]4[S:18][CH:19]=[CH:20][CH:21]=4)[N:23]=3)=[C:6]2[N:5]=[N:4]1

参加物

4

反応物 2

HCID 24841Hydrogen iodideHCID 1784819793-Methyl-4-oxo-N-(2-oxo-2-(thiophen-2-yl)ethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide

生成物 1

HCID 178481972HCID 178481972、化合物収率 89.3%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒2 回

反応条件

温度
80 °C

実験手順

A mixture of crude 3-methyl-4-oxo-N-(2-oxo-2-(thiophen-2-yl)ethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide (40 mg) in 3N HCl (3 mL) was heated at 80° C. overnight. After being cooled to room temperature, the mixture was left at 4° C. for 2 hours and the precipitate was filtered and washed successively with cold water, ethyl acetate and diethyl ether to give the a mixture of the hydrochloride and hydroiodide salts of the title compound (24 mg).

後処理

  1. temperatureAfter being cooled to room temperature
  2. filtrationthe precipitate was filtered
  3. washwashed successively with cold water, ethyl acetate and diethyl ether
  4. customto give

出典と根拠

ORDレコード
ord-d4c1abc50713406798b58db77ffdaf53
出典データセット
uspto-grants-2015_05
特許番号
US09024018B2

反応ノート

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