Hydrogen iodide → HCID 178456698、化合物

HRID 570947ノート

反応式

HRID 570947 の反応式
I.[O:2]=[C:3]1[N:8]([CH2:9][C:10]#[CH:11])[N:7]=[N:6][C:5]2=[C:12]([C:15](=[NH:26])[NH:16][CH2:17][C:18](=O)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:13]=[CH:14][N:4]12.I>Cl>[C:19]1([C:18]2[N:26]=[C:15]([C:12]3[N:13]=[CH:14][N:4]4[C:3](=[O:2])[N:8]([CH2:9][C:10]#[CH:11])[N:7]=[N:6][C:5]=34)[NH:16][CH:17]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

4

反応物 2

HCID 24841Hydrogen iodideHCID 178456701HCID 178456701、化合物

生成物 1

HCID 178456698HCID 178456698、化合物

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒2 回

反応条件

温度
80 °C

実験手順

A mixture of crude 4-oxo-N-(2-oxo-2-phenylethyl)-3-(prop-2-ynyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide (45 mg) in 3N HCl (4 mL) was heated at 80° C. overnight. After being cooled to room temperature, the mixture was left at 4° C. for 2 hours and the precipitate was filtered and washed successively with cold water, ethyl acetate and diethyl ether to give a mixture of the hydrochloride and hydroiodide salts of the title compound.

後処理

  1. temperatureAfter being cooled to room temperature
  2. filtrationthe precipitate was filtered
  3. washwashed successively with cold water, ethyl acetate and diethyl ether
  4. customto give

出典と根拠

ORDレコード
ord-610222cf550e477a95a04448054d7917
出典データセット
uspto-grants-2015_05
特許番号
US09024018B2

反応ノート

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