化工社化工社 化学情報印刷レポート · 研究参考用
Sodium ethoxide → Ethyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | Diethyl Maleate | HCID 5271566 | — |
| 反応物 | 3-Hydrazinopyridine | HCID 10909519 | — |
| 反応物 | 3-Hydrazinylpyridine dihydrochloride | HCID 17132489 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate | HCID 118023220 | — |
反応手順
In a preferred reaction, sodium ethoxide in an anhydrous ethanol are introduced into a reaction vessel and 3-hydrazinopyridine.dihydrochloride is added. The mixture is stirred and diethyl maleate is added. The mixture is heated at about 60° C. until most of the 3-hydrazinopyridine has reacted. The mixture is allowed to cool and the excess base is neutralized with acid. The crude ethyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate (10a) is conveniently isolated and purified by standard techniques.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09024031B1 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-973a67849011439b9851380da46bdb5c |
| 出典メモ | uspto-grants-2015_05 |