Formamide → 6-Iodoquinazolin-4-one
反応式
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([I:12])=[CH:8][C:3]=1[C:4](OC)=[O:5].[CH:13]([NH2:15])=O>>[I:12][C:9]1[CH:8]=[C:3]2[C:2](=[CH:11][CH:10]=1)[N:1]=[CH:13][NH:15][C:4]2=[O:5]参加物
3
実験手順
Methyl 2-amino-5-iodobenzoate (17.8 g, 64 mmol) was heated in 300 mL of formamide at 190° C. for 2 hours. The mixture was cooled to room temperature and the solid product was filtrated and dried in vacuum. The formed product 1403-174 was used without further purification. (10 g, 56.1%): LC-MS: 273 [M+1]+, 1H NMR (DMSO-d6): δ 7.46 (d, J=9.0 Hz, 1H), 8.10 (m, 2H), 8.36 (d, J=2.1 Hz, 1 H), 12.40 (s, 1H).
後処理
- filtrationthe solid product was filtrated
- customdried in vacuum
- customThe formed product 1403-174 was used without further purification
出典と根拠
- ORDレコード
- ord-5f5081b96f944a9a8f0992906fba70d9
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09024024B2
反応ノート
読み込み中…