Glycine → HCID 85831631、化合物

HRID 571274

反応式

HRID 571274 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])O[C:6]2=[O:15].[NH2:16][CH2:17][C:18]([OH:20])=[O:19]>C1(C)C=CC=CC=1>[CH3:13][O:12][C:11]1[CH:10]=[C:9]2[C:5](=[CH:4][C:3]=1[O:2][CH3:1])[C:6](=[O:15])[N:16]([CH2:17][C:18]([OH:20])=[O:19])[C:8]2=[O:14]

参加物

4

反応物 2

HCID 750GlycineHCID 6103565,6-Dimethoxy-1,3-dihydro-2-benzofuran-1,3-dione

生成物 1

HCID 85831631HCID 85831631、化合物収率 54%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
180 °C

実験手順

A suspension of 5,6-dimethoxyisobenzofuran-1,3-dione (491 mg, 2.359 mmol) and 2-aminoacetic acid (195 mg, 2.59 mmol) in toluene (10 ml) was heated under MW irradiation at 180° C. for 7 hours. The precipitate was collected by filtration, washed with toluene (5 ml) and dried to afford 2-(5,6-dimethoxy-1,3-dioxoisoindolin-2-yl)acetic acid as a off-white powder (335 mg, 1.263 mmol, 54% yield). MS/ESI+ 265.9 [MH]+.

後処理

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with toluene (5 ml)
  3. customdried

出典と根拠

ORDレコード
ord-78e7d23c5932456880b4fb15ca7d3b07
出典データセット
uspto-grants-2015_05
特許番号
US09024027B2

関連ノート

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