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2-(Trifluoromethyl)pyridine-4-carboxylic acid → (S)-N-(2-Chloro-4-(morpholin-2-yl)phenyl)-1-(4-cyanophenyl)-1H-pyrazole-4-carboxamide hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Trifluoromethyl)pyridine-4-carboxylic acid | HCID 14761447 | — |
| 反応物 | 1-(4-Cyanophenyl)-1H-pyrazole-4-carboxylic acid | HCID 43259425 | — |
| 反応物 | (S)-tert-butyl 2-(4-amino-3-chlorophenyl)morpholine-4-carboxylate | HCID 68325446 | — |
| 生成物 | (S)-N-(2-Chloro-4-(morpholin-2-yl)phenyl)-1-(4-cyanophenyl)-1H-pyrazole-4-carboxamide hydrochloride | HCID 71086869 | — |
反応手順
In analogy to example 83, step a) using 1-(4-cyanophenyl)-1H-Pyrazole-4-carboxylic acid (CAS 1152945-21-5)) instead of 2-(trifluoromethyl)-4-pyridinecarboxylic acid (CAS 131747-41-6) and (−)-(S)-2-(4-Amino-3-chloro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester (example 29a) instead of (+)-(R)-2-(4-Amino-2-fluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester. White solid. MS (ISP): 408.2 ([M+H]+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09029370B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-69103bb4c3384b87955445e8dbabdcde |
| 出典メモ | uspto-grants-2015_05 |