trans-2-Phenyl-1-cyclopropanecarbonyl chloride → trans-(4-Cycloheptylpiperazin-1-yl)-(2-phenylcyclopropyl)methanone

HRID 572002

反応式

HRID 572002 の反応式
[C:1]1([C@@H:7]2[CH2:9][C@H:8]2[C:10](Cl)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:13]1([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>>[CH:13]1([N:20]2[CH2:25][CH2:24][N:23]([C:10]([C@@H:8]3[CH2:9][C@H:7]3[C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[O:11])[CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

参加物

3

反応物 2

HCID 13656trans-2-Phenyl-1-cyclopropanecarbonyl chlorideHCID 7961661-Cycloheptylpiperazine

生成物 1

HCID 25196562trans-(4-Cycloheptylpiperazin-1-yl)-(2-phenylcyclopropyl)methanone

実験手順

This example was prepared according to Example 1 by employing trans-2-phenyl-1-cyclopropanecarbonyl chloride and 1-cycloheptylpiperazine, which is commercially available from, for example, Sigma-Aldrich. m/z (ES+) M+1=327.2; HPLC tR=1.90 min. 1H NMR (500 MHz, CDCl3) □7.26 (m, 2H), 7.22-7.13 (m, 1H), 7.09 (d, J=6.7 Hz, 2H), 3.86-3.50 (m, 4H), 2.60-2.42 (m, 6H), 1.95 (dt, J=5.1, 3.8 Hz, 1H) 1.83-1.73 (m, 2H), 1.71-1.60 (m, 3H), 1.58-1.31 (m, 8H), 1.24 (ddd, J=8.2, 6.1, 4.3 Hz, 1H).

出典と根拠

ORDレコード
ord-27491c46cdc249f5985255f7a1a195e2
出典データセット
uspto-grants-2015_05
特許番号
US09029381B2

関連ノート

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