Methyl 4-[(3,4-dimethylphenyl)(methyl)amino]-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinecarboxylate → 4-[(3,4-Dimethylphenyl)(methyl)amino]-3-(hydroxymethyl)-2-methyl-1(2H)-isoquinolinone
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([N:9]([CH3:26])[C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13](=[O:20])[N:12]([CH3:21])[C:11]=2[C:22](OC)=[O:23])[CH:5]=[CH:6][C:7]=1[CH3:8].[BH4-].[Li+].C1COCC1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[C:4]([N:9]([CH3:26])[C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13](=[O:20])[N:12]([CH3:21])[C:11]=2[CH2:22][OH:23])[CH:5]=[CH:6][C:7]=1[CH3:8]参加物
4
反応条件
- 温度
- 70 °C