Triethylamine → Ethyl 2-[4-(Methylsulfonamido)phenyl]acetate

HRID 572923ノート

反応式

HRID 572923 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>ClCCl>[CH3:21][S:22]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:6][CH:7]=1)(=[O:24])=[O:23]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 225219p-Aminophenylacetic acid ethyl ester

生成物 1

HCID 10038092Ethyl 2-[4-(Methylsulfonamido)phenyl]acetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The solution of ethyl 2-(4-aminophenyl)acetate (500 mg, 2.79 mmol) and triethylamine (0.58 mL, 4.18 mmol) in dichloromethane (30 mL) was added methanesulfonyl chloride (0.24 mL, 3.07 mmol) dropwise at room temperature and stirred overnight. The mixture was washed with brine, dried over sodium sulfate and evaporated under reduced pressure. The residue was purified by a standard method to give desired compound. LC-MS: m/z (M+H)=258.3

後処理

  1. washThe mixture was washed with brine
  2. dry with materialdried over sodium sulfate
  3. customevaporated under reduced pressure
  4. customThe residue was purified by a standard method

出典と根拠

ORDレコード
ord-fb2d1e9b58c144f7bd732f22ef461a7e
出典データセット
uspto-grants-2015_05
特許番号
US09029531B2

反応ノート

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