関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | 4-Bromopyridine | HCID 14268 | — |
| 試薬 | Sodium t-butoxide | HCID 23676156 | — |
| 触媒 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-phenylpyridin-4-amine | HCID 89945 | 20.25% |
反応手順
ANILINE (6.85 mL, 75.19 mmol) was added to 4-bromopyridine (9.9 g, 62.66 mmol), PALLADIUM(II) ACETATE (0.281 g, 1.25 mmol), XANTPHOS (2.175 g, 3.76 mmol) and SODIUM TERT-BUTOXIDE (8.43 g, 87.72 mmol) in toluene (500 mL) under nitrogen. The resulting mixture was stirred at 100 °C for 4 hours. The reaction mixture was evaporated to dryness and redissolved in EtOAc (200 mL), and washed sequentially with water (2 x 100 mL) and saturated brine (100 mL). The organic layer was dried over MgSO4, filtered and preadsorbed onto silica. The crude product was purified by flash silica chromatography, elution gradient 0 to 100% EtOAc in heptane. Pure fractions were evaporated to dryness to afford N-phenylpyridin-4-amine (2.160 g, 20.25 %) as a pale tan solid.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-3201a37afe8b4b36ad112c88df6755f7 |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
