化工社化工社 化学情報印刷レポート · 研究参考用
3-Hydroxybenzaldehyde → 3-(Dimethylaminomethyl)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Hydroxybenzaldehyde | HCID 101 | — |
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-(Dimethylaminomethyl)phenol | HCID 32896 | — |
反応手順
3-Hydroxybenzaldehyde (1.0 g), 2M dimethylamine in THF (5 mL), and sodium triacetoxyborohydride (2 g) in CH2Cl2 (10 mL) were stirred for 24 hours. The mixture was treated with methanol and chromatographed on silica gel with 2-25% ethyl acetate/hexanes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09029404B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-d708a61eaf2640978e694ace5edbc94a |
| 出典メモ | uspto-grants-2015_05 |