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Diethyl Ether → ethyl 4-fluoro-2-(2-methyl-1H-indol-5-yloxy)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | 2-methyl-1H-indol-5-ol | HCID 83336 | — |
| 反応物 | Benzoic acid, 2,4-difluoro-, ethyl ester | HCID 2737170 | — |
| 溶媒 | Diglyme | HCID 8150 | — |
| 生成物 | ethyl 4-fluoro-2-(2-methyl-1H-indol-5-yloxy)benzoate | HCID 67227223 | — |
反応手順
Ethyl 2,4-difluorobenzoate (1.14 g), K3PO4 (1.30 g) and 2-methyl-5-indolol (0.90 g) were stirred at 110° C. in diglyme (12 mL) for 24 hours. The mixture was cooled and poured into ether. The solution was washed three times with 1M NaOH solution, and with brine, and dried. The solution was then concentrated. The concentrate was chromatographed on silica gel with 10% ethyl acetate/hexanes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09029404B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-1ee6f62c08ad4d0db339638b3a8d1d3c |
| 出典メモ | uspto-grants-2015_05 |