関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | 4-Amino-2-chlorophenol | HCID 77578 | — |
| 反応物 | Benzoic acid, 2,4-difluoro-, ethyl ester | HCID 2737170 | — |
| 溶媒 | Diglyme | HCID 8150 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Ethyl 2-(4-amino-2-chlorophenoxy)-4-fluorobenzoate | HCID 67228057 | — |
反応手順
To a solution of ethyl 2,4-difluorobenzoate (6.48 g) and 4-amino-2-chlorophenol (5.0 g) in diglyme (40 mL) was added K3PO4 (7.39 g). The mixture was stirred at 110° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water, brine and dried over Na2SO4. The mixture was filtered, and the solvent was evaporated and the residue was loaded on a column and eluted with 10% ethyl acetate in hexane to give the product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09029404B2 |
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| 出典データセット | uspto-grants-2015_05 |
|---|
| ORD ID | ord-788b9a1f586a424c98e346ebf676b9f6 |
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| 出典メモ | uspto-grants-2015_05 |
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