戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 573256作成日：2026年10月25日

1-Naphthalenethiol → S-1-Naphthyl 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbothioate

https://huagongshe.com/reaction/573256

反応式

関与物質

役割名称HCID仕込み量
反応物1-NaphthalenethiolHCID 68259—
反応物2-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolecarboxylic acidHCID 66601457—
生成物S-1-Naphthyl 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbothioateHCID 86652913—

反応手順

A solution of 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylic acid (III-4, 200 mg) is reacted analogously to Example I-227 with naphthalene-1-thiol (88.0 mg). This gives, after chromatographic purification, S-1-naphthyl 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbothioate (100 mg, 37%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09029549B2
出典データセットuspto-grants-2015_05
ORD IDord-422e6be70d0b4e81a2cc44456008d1c1
出典メモuspto-grants-2015_05