関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Chlorobenzimidazole | HCID 78572 | — |
| 反応物 | 5-Bromoindoline | HCID 3411566 | — |
| 溶媒 | N,N-dimethylformamide N,N-dimethylacetamide | HCID 22628260 | — |
| 生成物 | 2-(5-Bromo-2,3-dihydro-1H-indol-1-yl)-1H-benzimidazole | HCID 66727872 | 69.4% |
反応手順
A mixture of 5-bromoindoline (1 g) and 2-chloro-1H-benzo[d]imidazole (0.770 g) in DMA/DMF (5 mL, 3/2) was stirred at 150° C. for 12 h, treated with water, and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (1.1 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09029536B2 |
|---|
| 出典データセット | uspto-grants-2015_05 |
|---|
| ORD ID | ord-382a041251144bd1a58a76f565fcab9f |
|---|
| 出典メモ | uspto-grants-2015_05 |
|---|
