Hydrochloric Acid → HCID 178456626、化合物

HRID 573328ノート

反応式

HRID 573328 の反応式
C[O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[C:13]3=[N:14][CH:15]=[CH:16][CH:17]=[C:12]3[N:11]([CH:18]([CH3:20])[CH3:19])[N:10]=2)=[CH:5][CH:4]=1.Cl>CO>[CH3:20][CH:18]([N:11]1[C:12]2[C:13](=[N:14][CH:15]=[CH:16][CH:17]=2)[C:9]([C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[N:8][CH:7]=2)=[N:10]1)[CH3:19]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 866889833-(6-Methoxypyridin-3-yl)-1-(1-methylethyl)-1H-pyrazolo[4,3-b]pyridine

生成物 1

HCID 178456626HCID 178456626、化合物収率 80.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 3-(6-methoxypyridin-3-yl)-1-(1-methylethyl)-1H-pyrazolo[4,3-b]pyridine (100 mg), MeOH (10 mL) and concentrated HCl (3 mL) was stirred at reflux for 24 h and then evaporated. The residue was treated with saturated NaHCO3 aqueous solution and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was suspended in IPE and collected by filtration to give the title compound (76 mg).

後処理

  1. temperatureat reflux for 24 h
  2. customevaporated
  3. additionThe residue was treated with saturated NaHCO3 aqueous solution
  4. extractionextracted with AcOEt
  5. dry with materialThe organic layer was dried over MgSO4
  6. concentrationconcentrated under reduced pressure
  7. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-6f510081efa34280a43c165ddab0dadb
出典データセット
uspto-grants-2015_05
特許番号
US09029536B2

反応ノート

読み込み中…