Dichloromethane → Methanone, (5-methyl-2-furanyl)phenyl-

HRID 573408

反応式

HRID 573408 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClCCl.[Cl-].[Al+3].[Cl-].[Cl-].[CH3:17][C:18]1[O:19][CH:20]=[CH:21][CH:22]=1>O>[CH3:17][C:18]1[O:19][C:20]([C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:8])=[CH:21][CH:22]=1

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 7412Benzoyl chlorideHCID 107972-MethylfuranHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 11679940Methanone, (5-methyl-2-furanyl)phenyl-

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Into a flask containing benzoyl chloride (206 g) and dichloromethane (2 L) was added aluminum chloride (200 g) while stirring. After 30 minutes at ambient temperature the flask was placed in a water bath and a condenser was connected through which 2-methylfuran (210 mL) was added dropwise over 30 minutes. The resulting mixture was stirred for 7 hours then carefully poured into cold water (3 L). The organic layer was collected, washed with water and concentrated to afford (5-methylfuran-2-yl)(phenyl)methanone as an oily product (220 g).

後処理

  1. additionwas added dropwise over 30 minutes
  2. stirringThe resulting mixture was stirred for 7 hours
  3. customThe organic layer was collected
  4. washwashed with water
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-74df55f349bb4b149720c0273be61776
出典データセット
uspto-grants-2015_05
特許番号
US09029565B1

関連ノート

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