2,4-Dimethyl-3-cyclohexene carboxaldehyde → 1,3-Dioxane, 2-(2,4-dimethyl-3-cyclohexen-1-yl)-5-methyl-5-(1-methylpropyl)-

HRID 573460

反応式

HRID 573460 の反応式
[CH:1]([C:5]([CH3:10])([CH2:8][OH:9])[CH2:6][OH:7])([CH2:3][CH3:4])[CH3:2].[CH3:11][CH:12]1[CH:17]=[C:16]([CH3:18])[CH2:15][CH2:14][CH:13]1[CH:19]=O>>[CH:1]([C:5]1([CH3:10])[CH2:8][O:9][CH:19]([CH:13]2[CH2:14][CH2:15][C:16]([CH3:18])=[CH:17][CH:12]2[CH3:11])[O:7][CH2:6]1)([CH2:3][CH3:4])[CH3:2]

参加物

3

反応物 2

HCID 933752,4-Dimethyl-3-cyclohexene carboxaldehydeHCID 980761,3-Propanediol, 2-methyl-2-(1-methylpropyl)-

生成物 1

HCID 160707521,3-Dioxane, 2-(2,4-dimethyl-3-cyclohexen-1-yl)-5-methyl-5-(1-methylpropyl)-

実験手順

An aqueous NaOH solution (30%, 420 g) was added at room temperature into a stirred mixture of 2,3-dimethyl pentanal (325 g, prepared as above in EXAMPLE II) and aqueous formaldehyde solution (CH2O) (30%, 722 g) while the reaction temperature was allowed to rise up to about 80° C. due to the exothermic reaction. After the addition was completed, the reaction mixture was cooled to about 40° C. The organic phases was separated and fractionally distilled to afford 2-sec-butyl-2-methyl-propane-1,3-diol (277 g). 2-sec-Butyl-2-methyl-propane-1,3-diol was reacted with 2,4-dimethyl-cyclohex-3-enecarbaldehyde to afford 5-sec-butyl-2-(2,4-dimethyl-cyclohex-3-enyl)-5-methyl-[1,3]dioxane according to previous disclosure (See, for example, U.S. Pat. No. 6,444,637).

出典と根拠

ORDレコード
ord-2dbb87e1e4a544c1baa0909fd54a0fea
出典データセット
uspto-grants-2015_05
特許番号
US09029576B2

関連ノート

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