Sodium Bicarbonate → 8-Aminospiro[3.5]non-7-EN-6-one
反応式
[OH:1][C:2]1[CH2:10][C:6]2([CH2:9][CH2:8][CH2:7]2)[CH2:5][C:4](=O)[CH:3]=1.C([O-])(=O)C.[NH4+:16].C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1.C(O)(=O)C>[NH2:16][C:4]1[CH2:5][C:6]2([CH2:9][CH2:8][CH2:7]2)[CH2:10][C:2](=[O:1])[CH:3]=1参加物
6
実験手順
10 g 8-hydroxyspiro[3.5]non-7-en-6-one and 10.1 g ammonium acetate are dissolved in 100 ml toluene and 3.2 ml acetic acid. The mixture is refluxed for 2 hours using a Dean-Stark trap. After cooling to room temperature the mixture is cautiously added to 200 ml of a saturated solution of sodium bicarbonate and 100 g ice. Then the mixture is stirred for 15 minutes, the solid product is collected by filtration and dried at 50° C. in vacuo.
後処理
- temperatureThe mixture is refluxed for 2 hours
- filtrationthe solid product is collected by filtration
- customdried at 50° C. in vacuo
出典と根拠
- ORDレコード
- ord-b45f53fe787c4b2aa35b8b1646ab0e5f
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09029544B2
反応ノート
読み込み中…