Sodium Methoxide → 5-Methoxy-3-methylpicolinonitrile

HRID 574120ノート

反応式

HRID 574120 の反応式
Br[C:2]1[CH:3]=[C:4]([CH3:10])[C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH3:11][O-:12].[Na+]>CO>[CH3:11][O:12][C:2]1[CH:3]=[C:4]([CH3:10])[C:5]([C:8]#[N:9])=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 207750075-Bromo-3-methylpyridine-2-carbonitrile

生成物 1

HCID 573261205-Methoxy-3-methylpicolinonitrile収率 79%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-Bromo-3-methylpicolinonitrile (50, 35 g, 0.18 mol) was added to a solution of sodium methoxide (18 g, 0.54 mol) in methanol (200 mL), and the mixture was heated at reflux for 12 h. The solution was cooled to room temperature and concentrated to one third of its volume. The concentrated solution was diluted with water (150 mL), and the products were extracted with chloroform (3×50 mL). The combined extracts were washed with water (2×50 mL), brine (50 mL), dried with sodium sulfate and filtered through a pad of silica gel, washing with chloroform, to produce 51 as an off-white solid (21 g, 79%): mp 80-81° C. IR (film) 2225, 1645, 1589 cm−1; 1H NMR (300 MHz, CDCl3) δ 8.06 (d, J=2.6 Hz, 1H), 7.03 (d, J=2.4 Hz, 1H), 3.83 (s, 3H), 2.43 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 157.65, 139.99, 137.68, 125.05, 120.52, 116.76, 55.84, 18.71; EIMS m/z (rel intensity): 148 (M+, 100); CIMS m/z (rel intensity): 149 (MH+, 100).

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 12 h
  3. concentrationconcentrated to one third of its volume
  4. additionThe concentrated solution was diluted with water (150 mL)
  5. extractionthe products were extracted with chloroform (3×50 mL)
  6. washThe combined extracts were washed with water (2×50 mL), brine (50 mL)
  7. dry with materialdried with sodium sulfate
  8. filtrationfiltered through a pad of silica gel
  9. washwashing with chloroform

出典と根拠

ORDレコード
ord-689c893472c2420b94729900c05aedcb
出典データセット
uspto-grants-2015_05
特許番号
US09034870B2

反応ノート

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