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HRID 574151作成日:2026年10月24日

Hydrochloric Acid → Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochloride

https://huagongshe.com/ja/reaction/574151

反応式

関与物質

役割名称HCID仕込み量
反応物Hydrochloric AcidHCID 313—
反応物Ethyl 1-({[(tert-butoxycarbonyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylateHCID 66801809—
溶媒DichloromethaneHCID 6344—
溶媒1,4-DioxaneHCID 31275—
生成物Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochlorideHCID 89780476—

反応手順

262 mg (0.61 mmol) of the compound of Example 17A were dissolved in 4 ml of dichloromethane, and 4 ml of a 4N solution of hydrogen chloride in dioxane were added. The solution was stirred at RT for 3 h and then freed from the volatile components on a rotary evaporator. The residue was dried under high vacuum. This gave 223 mg (quant.) of the title compound.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09034855B2
出典データセットuspto-grants-2015_05
ORD IDord-63ef24af7ed74888b706354e023f6057
出典メモuspto-grants-2015_05