Hydrochloric Acid → 1-Cyclobutylpiperazine hydrochloride

HRID 574167ノート

反応式

HRID 574167 の反応式
[CH:1]1([N:5]2[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[ClH:18]>CO>[ClH:18].[CH:1]1([N:5]2[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57423951Tert-butyl 4-cyclobutylpiperazine-1-carboxylate

生成物 1

HCID 230903791-Cyclobutylpiperazine hydrochloride収率 82%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To the mixture of tert-butyl 4-cyclobutylpiperazine-1-carboxylate (48 g, 200 mmol) in MeOH (100 mL) was added 2.0 M HCl in MeOH (400 mL) carefully at 0° C. The mixture was stirred at rt for 5 h, concentrated under reduced pressure to afford the desired compound 1-cyclobutylpiperazine hydrochloride (35 g, 82%) [LCMS: Rt=0.94 min, m/z 141.3 (M+H)+].

後処理

  1. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-0f9117a098e84406bf009e2d1faac3c8
出典データセット
uspto-grants-2015_05
特許番号
US09034874B2

反応ノート

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