関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidin-4-ol | HCID 79341 | — |
| 反応物 | 6-Chloropyridazin-3-ol | HCID 252828 | — |
| 溶媒 | Diisopropylethylamine | HCID 81531 | — |
| 生成物 | 6-(4-Hydroxypiperidin-1-yl)pyridazin-3-ol | HCID 86721992 | 100% |
反応手順
To a solution of 6-chloropyridazin-3(2H)-one (2.6 g, 20 mmol) in DIPEA (30 mL) was added piperidin-4-ol (2.4 g, 20 mmol) and the mixture was stirred at 120° C. for 8 h. The reaction mixture was concentrated under reduced pressure to afford the crude product, which was further purified by silica gel chromatography (DCM/MeOH=20/1) to afford the title compound (3.9 g, 100%) as a yellow solid. [LCMS: Rt=0.77 min, m/z 196.2 (M+H)+].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09034874B2 |
|---|
| 出典データセット | uspto-grants-2015_05 |
|---|
| ORD ID | ord-fb9277390329402a9e2c05780f2766ab |
|---|
| 出典メモ | uspto-grants-2015_05 |
|---|
