Benzyl Bromide → 2-Benzyloxy-5-bromopyridine

HRID 574175ノート

反応式

HRID 574175 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[CH2:10]([O:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 7498Benzyl BromideHCID 5995285-Bromo-2-hydroxypyridine

生成物 1

HCID 111081912-Benzyloxy-5-bromopyridine収率 95%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
100 °C

実験手順

To a solution of 5-bromopyridin-2(1H)-one (1.28 g, 7.36 mmol) and Ag2CO3 (3 g, 11.04 mmol) in toluene (50 mL) was added (bromomethyl)benzene (1.25 g, 7.36 mmol) dropwise and the reaction mixture was stirred at 100° C. over night. The reaction mixture was filtered through a short pad of silica gel and washed with DCM. The filtrate was concentrated to yield the title compound as light yellow oil (1.8 g, 95%).

後処理

  1. filtrationThe reaction mixture was filtered through a short pad of silica gel
  2. washwashed with DCM
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-9665073dbe354264a876e074aa0deb34
出典データセット
uspto-grants-2015_05
特許番号
US09034874B2

反応ノート

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